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Original Research 


Cardiovascular performance following continuous positive airway pressure in patients with severe obstructive sleep apnea

Khanaphaphon Wuttiumporn, Wilaiwan Khrisanapant, Orapin Pasurivong, Watchara Boonsawat, Banjamas Intarapoka.


Abstract
Background: Obstructive sleep apnea (OSA) may lead to decreased exercise capacity. We investigated whether continuous positive airway pressure (CPAP) treatment improved cardiovascular performance in OSA patients.
Methods: Forty healthy subjects (control group) and 40 severe OSA patients were recruited. The two groups were matched for age, gender, and body mass index. OSA patients were assigned to CPAP and non-CPAP treatment groups in equal numbers. All subjects underwent cardiopulmonary exercise testing (CPET) using a treadmill and an incremental protocol until symptom limitation (Day 0). CPET was repeated at Day 180 in the CPAP treatment group.
Results: OSA patients had lower maximal oxygen consumption (V’O2max) (1666.3 ± 451.3 vs. 1375.6 ± 227.7 ml/min, 28.2 ± 5.5 vs. 18.9 ± 3.8 ml/min/kg) (p < 0.001), higher maximal V’E/V’CO2 (p < 0.01), V’E/V’O2 (p < 0.001), heart rate (HR) reserve (p < 0.001), and blunted HR recovery (HRR) at 1-5 min (p < 0.001) compared to controls. V’O2max was negatively correlated with AHI (R2 = 0.1363, p < 0.05). In the CPAP but not in non-CPAP treatment group, both V’O2max (p < 0.05), HRR (p < 0.001), and HR reserve (p < 0.05) were improved on Day 180 compared to Day 0.
Conclusion: Our study demonstrates that CPAP therapy for six months provides clinical benefits by improving cardiovascular performance.

Key words: Obstructive sleep apnea, continuous positive airway pressure, cardiopulmonary exercise testing, heart rate recovery


 
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How to Cite this Article
Pubmed Style

Wuttiumporn K, Khrisanapant W, Pasurivong O, Boonsawat W, Intarapoka B. Cardiovascular performance following continuous positive airway pressure in patients with severe obstructive sleep apnea. Sleep Hypn. 2018; 20(3): 174-183.

Web Style

Wuttiumporn K, Khrisanapant W, Pasurivong O, Boonsawat W, Intarapoka B. Cardiovascular performance following continuous positive airway pressure in patients with severe obstructive sleep apnea. https://www.sleepandhypnosis.com/?mno=276974 [Access: June 23, 2026].

AMA (American Medical Association) Style

Wuttiumporn K, Khrisanapant W, Pasurivong O, Boonsawat W, Intarapoka B. Cardiovascular performance following continuous positive airway pressure in patients with severe obstructive sleep apnea. Sleep Hypn. 2018; 20(3): 174-183.


Vancouver/ICMJE Style

Wuttiumporn K, Khrisanapant W, Pasurivong O, Boonsawat W, Intarapoka B. Cardiovascular performance following continuous positive airway pressure in patients with severe obstructive sleep apnea. Sleep Hypn. (2018), [cited June 23, 2026]; 20(3): 174-183.


Harvard Style

Wuttiumporn, K., Khrisanapant, . W., Pasurivong, . O., Boonsawat, . W. & Intarapoka, . B. (2018) Cardiovascular performance following continuous positive airway pressure in patients with severe obstructive sleep apnea. Sleep Hypn, 20 (3), 174-183.


Turabian Style

Wuttiumporn, Khanaphaphon, Wilaiwan Khrisanapant, Orapin Pasurivong, Watchara Boonsawat, and Banjamas Intarapoka. 2018. Cardiovascular performance following continuous positive airway pressure in patients with severe obstructive sleep apnea. Sleep and Hypnosis, 20 (3), 174-183.


Chicago Style

Wuttiumporn, Khanaphaphon, Wilaiwan Khrisanapant, Orapin Pasurivong, Watchara Boonsawat, and Banjamas Intarapoka. "Cardiovascular performance following continuous positive airway pressure in patients with severe obstructive sleep apnea." Sleep and Hypnosis 20 (2018), 174-183.


MLA (The Modern Language Association) Style

Wuttiumporn, Khanaphaphon, Wilaiwan Khrisanapant, Orapin Pasurivong, Watchara Boonsawat, and Banjamas Intarapoka. "Cardiovascular performance following continuous positive airway pressure in patients with severe obstructive sleep apnea." Sleep and Hypnosis 20.3 (2018), 174-183. Print.


APA (American Psychological Association) Style

Wuttiumporn, K., Khrisanapant, . W., Pasurivong, . O., Boonsawat, . W. & Intarapoka, . B. (2018) Cardiovascular performance following continuous positive airway pressure in patients with severe obstructive sleep apnea. Sleep and Hypnosis, 20 (3), 174-183.


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